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Pharmacological Basis of the Yin-nourishing and Yang-invigorating Actions of Cordyceps

2007-3-6 4:19:39 Viewed: [ Font:Large Medium Small] [ Close]

 

The popular Yin-nourishing and Yang-invigorating Chinese herb, Cordyceps sinensis (Berk) Sacc., was examined in a study in order to establish the pharmacological basis for its actions. The effects of wild and cultured Cordyceps on concanavalin A (Con A)-stimulated splenocytes, an in vitro bioassay for Yin-nourishment , and myocardial ATP generation capacity, an ex vivo bioassay for Yang-invigoration , were investigated in mice. The outcome showed that methanolic extracts of wild and cultured Cordyceps increased both the Con A-stimulated splenocyte proliferation in vitro and myocardial mitochondrial ATP generation ex vivo in mice, with no considerable difference in the strength of action between the wild or cultured types of Cordyceps. While the immuno-potentiating effect was associated with the increase in interleukin II production, the stimulation of myocardial ATP generation was paralleled by an enhancement in mitochondrial electron transport. In comparison with other Yin and Yang tonifying Chinese herbs, Cordyceps was found to possess both Yin-nourishing and Yang-invigorating activities, with a lower potency in both types of action.





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