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main-page >> TCM-Info >> DietTherapy >> Text
Green Tea Slows Down Plaque Formation In Huntington s Disease

2007-2-28 5:30:30 Viewed: [ Font:Large Medium Small] [ Close]


The incurable disease is hereditary and has a prevalence of 1 in every 15,000 persons. In Germany, about 8,000 cases are currently known whereas in the US, 30,000 people have HD. If a child inherits a mutated Huntington s gene from one affected parent, the disease inevitably develops, usually between the ages of 30 and 50. As a result, the nerve cells progressively degenerate in the areas of the brain that control movement and that are involved in memory and emotions. Ten to 30 years after the onset of the disease, Huntington s chorea leads to death. Foundation under Public Law Directors: Prof. Walter Birchmeier, PhD., Dr. jur. Stefan Schwartze Member of the Hermann von Helmholtz Association of National Research Centres In 1993, scientists discovered the gene that encodes the protein huntingtin. A mutation in this protein causes the disease and results in the aggregation of the mutant huntingtin protein within the cell nuclei of brain neurons.


In 1997, Dr. Wanker was able to demonstrate that these deposits or aggregates consist of misfolded huntingtin molecules. In the protein factories of the nerve cells of people with Huntington s disease, too many glutamine building blocks have been inserted into the amino acid sequence of huntingtin.

Due to the elongated polyglutamine chains which are formed, the protein loses its normal structure and can no longer be disposed of. Scientists hypothesize that these protein aggregates are toxic to nerve cells.

According to the findings of Dagmar Ehrnhoefer and Dr. Wanker, however, the substance epigallocatechin-3-gallate (EGCG) extracted from green tea slows down this aggregation process.

The research group hopes that these findings will be the starting point for developing a novel drug treatment for HD and related diseases in which misfolded proteins occur.





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