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+380636018551
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Email:yizi_06@yahoo.com.cn |
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Miss Wang +380937434009 |
Miss Wang +380636018551 |
Email:yizi_06@yahoo.com.cn |
Address:Bei Xi Liu Lu Zhan Dian Zi Bo Shan Dong China |
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Gufang Chinese medicine complicated diseases research center is located at Shan Dong Province Zi Bo City, ZhangDian Bei Xi Liu Road; Zi Bo is situated between LuZhong mountain area and LuBei champagne, located at a unique location, its south joins with TaiShan, its north is near by Yellow River, its west is connected with Spring City JiNan, its east is near by beach cities-QingDao, YanTai and WeiHai; it is one of ShanDong Province's five main tourist spots and it is one of the eight tourism city.
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Dr. Wang Yong, character Shurun, of Han Nationality, is born to the Chinese medicine aristocratic family, he has inherited the essence of traditional Chinese medicine, he uses ancient secret remedies as the base and he complies, matches the results with the special characteristics of modern chronic diseases, high possibility contracted diseases, complicated diseases associated with drugs resistance, …….
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| Viagra may help heart in muscular dystrophy |
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| 2008-5-13 21:05:17 Viewed: [ Font:Large Medium Small] [ Close] |
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A Canadian study involving mice shows that anti-impotence pills might protect the hearts of people with a common form of muscular dystrophy, researchers said on Monday.
Canadian researchers gave sildenafil, the active ingredient in drug maker Pfizer Inc's Viagra, to mice with an animal version of Duchenne muscular dystrophy, and found that it improved their heart performance.
They said it would be premature to give Viagra to people with the disease, but said the results indicate the drug potentially could be used to prevent or delay heart failure in children with Duchenne muscular dystrophy.
The mice were given doses of the drug comparable to those administered to treat erectile dysfunction in men. The study, published in the Proceedings of the National Academy of Sciences, showed that sildenafil cut the levels of damage to contracting heart muscle cells.
"If you don't give the sildenafil, the heart of these mice doesn't function as well as normal mice, and they are more susceptible to stress-induced cell death," said researcher Christine Des Rosiers of the Montreal Heart Institute.
She said in an interview the drug worked to improve heart performance in the mice by preventing the breakdown of a naturally occurring chemical. Called cyclic guanosine monophosphate, or cGMP, it is involved in a number of cellular signaling pathways, the researchers said.
Other impotence drugs also affect the chemical cGMP, including vardenafil, sold by Schering Plough under the brand name Levitra, and tadalafil, sold by Eli Lilly and Co. under the brand name Cialis.
Duchenne muscular dystrophy is an inherited wasting disease characterized by weakness and progressive degeneration of the muscles, including the heart muscle. It begins in the legs and pelvis, and later affects the whole body. Most people with the disease must use a wheelchair by about age 12.
It is caused by a genetic mutation of dystrophin, a protein vital to muscle cells.
Heart problems can appear at around age 10 and they progress quickly, affecting most people with the disease by age 20. These heart problems are an important cause of death among patients with muscular dystrophy.
Sildenafil was developed as a heart drug and is widely prescribed for erectile dysfunction as well as pulmonary hypertension. The researchers said discussions are under way about possible future studies using the drug in patients with muscular dystrophy.
"There's a lot of information on this drug that shows it appears to be relatively safe in adults," Des Rosiers said, while emphasizing that future human clinical trials are needed before doctors prescribe it for heart trouble in these patients.
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