This syndrome is characterized by persistent proteinuria and/or hematuria and renal insufficiency that progresses slowly over years. This disease is a multietiological disease which has the possibility to progress to chronic nephritis with course of disease more than one year (gradually developing). It’s prone in adults and male than female. Among them, few cases develop from acute nephritis and mostly occur without symptoms and disease history. Clinically it’s classified into three types:
(1) normal form
(2) hypertensive form
(3) acute form
The causes of this disease is still unknown but is probably due to lower immune system that will leads to infection by different microbes, or the body immune system could not produce enough antibodies to eliminate cause of disease and leads to high immune complex(toxic to body) remain in body and chronic nephritis.
Renal biopsy typically reveals a variable combination of proliferative, membranous, and sclerotic changes, depending on the causative glomerulopathy. Arteriosclerosis, induced by secondary hypertension, is a common finding in the renal vasculature. Tubulointerstitial inflammation and scarring are frequent additional findings and portend a poor prognosis.
Modern therapy uses diuresis, decreases hypertension, decreases inflammatory symptoms and other symptomatic treatments. The usage of glucocorticoids and immunesuppressive agents are also often used. It is effective in some chronic glomerilonephritis but there are lots of side effects and in total the predicted results are comparatively poor.
Clinical treatment results
There were 218 cases using traditional Chinese medicine and from it 215 cases recovered. 52 cases recovered in 60 days, 115 cases recovered in 40 days and 48 cases in 30 days. Edema started to decrease fastest in 3days and latest in 15 days.